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Clinical trials show that patients typically regain significant weight after discontinuation

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In case of mortality within 5 postoperative days, patients were defined as PHLF when bilirubin and prothrombin time were altered according to the forementioned classification

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This triggers the MAPK cascade, such that Ras-GTP activates Raf [also called MAPK kinase kinase (MAPKKK)], which in turn activates MEK1/2 [MAPK kinase (MAPKK)]