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11serious AEs (9 liraglutide, 2 placebo) were reported, none related to the trial intervention

They found that for FDA approved GLP-1s for weight loss, liraglutide (Saxenda) and semaglutide (Wegovy), the percent of side effects reported was as follows: Nausea: 42.2% Diarrhea: 21.9% Vomiting: also 21.9% Constipation: 8.4% They report that although the incidence of side effects were similar among medications, semaglutide had the greatest risk of nausea, diarrhea, and vomiting, whereas liraglutide had the greatest risk of upper abdominal pain

Even under the new self-pay pricing, Zepbound from Eli Lilly now ranges in cost from $299 to $449 per month, depending on dosage

Wegovys approval was based on the STEP study

Meanwhile, oral semaglutide has shown cardiovascular safety, with outcome data continuing to evolve

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