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Patients should undergo comprehensive cardiovascular assessment before initiating Zepbound, including blood pressure measurement, lipid panel, hemoglobin A1c (if diabetic or prediabetic), and electrocardiogram if clinically indicated

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15,226,227 Recent therapeutic approaches focus on aldose reductase inhibitors (ARIs), such as epalrestat and ranirestat, which have shown promise in reducing sorbitol accumulation and ameliorating neuropathic symptoms in clinical trials

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