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As a ghrelin-receptor agonist, it both stimulates GH release and suppresses somatostatin tone, and it's studied for increasing the amplitude of GH pulses

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UPR, Unfolded Protein Response

Semaglutide, a GLP-1 receptor agonist, primarily works by enhancing insulin secretion, reducing appetite, and slowing gastric emptying, which has led to significant weight loss and improved glycemic control