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First, it was shown in vitro that treatment of astrocytes with acetyl-L-carnitine (30-100 M) induces vitagene HO-1 in a dose- and time-dependent manner and that this effect was associated with up-regulation of another vitagene HSP60 as well as high expression of the redox-sensitive transcription factor Nrf2 in the nuclear fraction of treated cells [121]

Pathway analysis and gene set enrichment analysis on differentially expressed genes were performed using metascape web tool (metascape.org) 48 and GSEA ( 49 , and selected annotated gene lists from a gene ontology database ( were matched with differentially expressed genes

Stanford University research showed: COX-2 inhibitors slow bone tissue growth and fracture healing [36]

This means that they penetrate deeper into the skin

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