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Antiamyloid treatments such as lecanemab and donanemab can have side effects

Neumann J, Kufler B, Gergs U (2019) Which phosphodiesterase can decrease cardiac effects of 5-HT4 receptor activation in transgenic mice

When caloric intake drops significantly, the thyroid may reduce hormone output as a protective mechanism

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As a small molecule rather than a biologic peptide, orforglipron can be manufactured using conventional pharmaceutical synthesis methods at a fraction of the cost required for peptide production