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Common adverse effects include dry skin, chapped lips, dry and irritated eyes, nosebleeds, sun-sensitive skin, worsening acne, and, in serious cases, mood disorders (eg, depression, anxiety) and birth defects or other risks to a fetus

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The procedures used to ligate the DNA sequences coding for the peptide or GLP-1 peptide, the promoter and optionally the terminator and/or secretory signal sequence, respectively, and to insert them into suitable vectors containing the information necessary for replication, are well known to persons skilled in the art (cf., for instance, Sambrook et al., supra )

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