Notably, primary bile acid biosynthesis was exclusively enriched at the early phase, suggesting a rapid development of bile acid production function in iHLOs at this stage
10.1016/0006-8993(93)91182-R 309 WolakM
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Cumulating evidence has indicated that mitochondrial metabolism supports tumor progression not only by serving as a major source of ATP, but also by providing key metabolites for macromolecule synthesis and signaling transduction during tumorigenesis [2]
These outcomes represent a substantial advancement over existing pharmacological options for obesity, with 89-96% of participants achieving at least 5% weight loss and 55-63% achieving 20% or greater weight reduction
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