Moreover, overexpression of specific GSTs can also affect chemoresistance, whereas polymorphisms that decrease GST activity are associated with a high risk of developing cancer [72]
Interestingly, CD8 + T toxic cells, the major executors of antitumor immunity, has been reported that ferroptosis in pathologically neutrophils induces the release of oxygenated lipids and further suppress the activity of T cells, which impede the antitumor immunity [232, 233]
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While we used several markers (including SA--gal, lipofuscin, cyclin-dependent kinase inhibitors, SASP components and transcriptional senescence signatures) to characterize senescence in these models, we have to acknowledge the limitations of our study given the inherent heterogeneity of senescent cells
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