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While both gene categories imply Ubx-RNA binding events coordinating splicing, two distinct mechanisms seem at play: the target genes regulated at both transcription and splicing levels largely depend on Ubx-DNA binding ability to regulate splicing, which cannot be dissociated from its RNA binding activity (Figure 1M)

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The difference is where the structure lives: Part 61 governs individual pilots and their certificate requirements

doi: 10.1126/scitranslmed.adp0004 113 RoeK