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Impaired fat oxidation is part of the obese phenotype (4143) and a key barrier to weight loss maintenance (44,45)

While these changes typically require extended exposure at high levels, they represent a real risk of excessive or prolonged use

Semisotnov et al., 1996

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Semaglutide 2.4 mg in participants with metabolic dysfunction-associated steatohepatitis: baseline characteristics and design of the phase 3 ESSENCE trial