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Proper technique reduces frequency, but occasional bruises are normal

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Therefore, it is expected to become the next generation of new antidepressants with fewer side effects (79)

Mechanistically, NETosis provides a biologically plausible link: NETs and NET-derived components (histones, MPO, NE, extracellular DNA) induce endothelial activation and dysfunction and promote platelet capture, fibrin deposition, and contact-pathway/coagulation activation, thereby converting neutrophil priming into endothelial injury and microvascular thrombotic events [69]

disentangling the amylin-specific contribution from the GLP-1 contribution is one of the interpretive challenges these trials leave open