Split dosing protocols (dividing the daily dose into two administrations) have been explored but generally show no significant advantage over once-daily dosing
falciparum has no identified Nrf2 orthologue and so likely lacks a KEAP1-Nrf2 mediated antioxidant response, which suggests that the SFN-GSH conjugate should only cause oxidative stress in parasites
Zhang H, Li T, Li S, Liu F
Swimming duration decreased from 75.0 1.8 s in the normal control group (NaCl, 0.9%) to 15.0 1.4 s in the negative control group (KET)
The KLOW peptide blend was developed with this research focus in mind
A reduction in the mRNA level of inflammatory mediators (iNOS, IL-6, IFN-, and TNF-) and increased expression of HSP 70 and 90 and antioxidant proteins such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2, and GST-pi were observed (Park et al., 2020)