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This is primarily because overweight is often associated with hormonal disorders for instance, in the so-called polycystic ovary syndrome, which can impair fertility." And further: "When weight normalizes and metabolism improves, it has an overall positive effect on fertility

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APAP-induced hepatotoxicity is mainly caused by the production of N-acetyl-p-benzoquinone imine (NAPQI), a highly reactive intermediate formed predominantly via the cytochrome P450 2E1 (CYP2E1)