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Ziyad Al-Aly, a clinical epidemiologist at WashU Medicine and Chief of Research and Development Service at the VA Saint Louis Health Care System

Tumor microenvironment and differential responses to therapy

These medications: Suppress appetite Slow gastric emptying Enhance glucose-dependent insulin release after meals Reduce glucagon secretion (which otherwise raises blood glucose) Support weight loss, particularly reduction in visceral adiposity Break the metabolic doom loop For patients with cardiovascular disease or glucose dysregulation, GLP-1based therapies can offer both metabolic and cardiovascular benefit when used appropriately within a supervised clinical framework

Bulk-forming fiber supplements (psyllium, methylcellulose) should be separated from other oral medications by approximately 2 hours, as they may affect absorption of some drugs

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