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However, substituting the ethoxy with larger aliphatic ether groups was better tolerated both in terms of TRF1 TRFH binding and aqueous solubility ( 30 , 31 , 32 )

Researchers handle the compound following institutional safety protocols, chemical handling guidelines, and approved standard operating procedures to minimize risk and ensure experimental integrity

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This difference in absorption rates explains why most clinical studies have focused on injectable forms of the medication