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Investigational therapiesincluding endothelin receptor antagonists (ERAs), nuclear factor erythroid 2related factor 2 (Nrf2) activators, and gut microbiota modulatorsare under active evaluation
Most TRICARE contractors require at least 90 days of metformin use or documented intolerance (GI side effects are the most common reason for discontinuation)
10.1111/dom.16376 36 KnopF
For coverage, insurance companies have been requiring that patients have a documented diagnosis of diabetes and have had an inadequate response or intolerable side effects from 3 or 4 other medications
This step is crucial for ensuring proper dosing
The tier placement and associated cost-sharing are plan-specific, not just region-specific
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