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GIP receptor activation enhances insulin secretion, improves fat metabolism, and may contribute to central nervous system effects on appetite that go beyond what GLP-1 alone can achieve

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L-carnitine plays a crucial role in male fertility, primarily due to its high concentration in the epididymis and spermatozoa (approximately 2000 times higher than in plasma) and its essential function in transporting fatty acids for mitochondrial energy production 13

For an obese diabetic, discontinuing a GLP-1 can spike glucose and weight, putting them at higher risk for an infection or wound to heal more slowly

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