There was also an improvement in the ratio of GSSG to GSH, with the largest decrease in this ratio among those taking the higher dose in the first and second weeks
10.1155/2024/5698119 19 ChhatreS.NesariT.SomaniG.KanchanD.SathayeS
evaluated the association between UA, cerebrospinal fluid biomarkers of AD and longitudinal cognitive decline in a follow-up period of 2.9 years ( n = 1064, including 271 healthy subjects, 596 with MCI, and 197 with AD) [112]

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Toxicity: Adverse effects to SAMe are rare but may include inappetence, vomiting, lethargy, and agitation after initial treatment
doi: 10.3389/fcvm.2022.860322