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Another observation to take into account is that, although pentoxifylline is a well-tolerated drug, it has several dose-related adverse effects including diarrhea, dyspepsia, constipation, confusion, seizures, hypotension, anaphylactoid reaction and hemorrhage (Tanikella et al., 2008

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It also cautions that oral absorption is less predictable, so the trade-off is tolerability against consistency of exposure

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