can you use glp 1 and dpp4 together Linagliptin:The Mechanism: How Does It Work? DPP-4 inhibitors are based on incretin physiology. After a meal, the gut releases GLP-1, which enhances insulin secretion under hyperglycemic conditions suppresses glucagon. However, GLP-1 GLP 1 Receptor Agonists and

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These medications potently and selectively inhibit the enzymatic activity of DPP-4, enhancing the effectiveness of GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), which are the primary incretins (endogenous glucoregulatory peptides, [39,40,41])

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