Last summer, a WIRED investigation found it shockingly easy to access GLP-1s
GLP-1R is expressed in the brainstem nucleus tractus solitarius, in the hypothalamic arcuate nucleus, in the vagus nerve, in the stomach, and in the heart
Xie, Y., Bowe, B
Unlike currently approved weight loss medications, retatrutide works as a triple agonist, meaning it targets three different hormone receptors: GIP, GLP-1, and glucagon receptors
The comparative effectiveness of an expanded 2-year on-treatment analysis that followed patients who stay on the exposure or comparator therapies for a prolonged time showed concordant results with the 1-year on-treatment analysis (Supplementary Table 25)
Clinical perspective SGLT2is and GLP-1RAs exhibit clinical benefits on glycemic control, systolic blood pressure (SBP), body weight, and dyslipidemia, which may all partly contribute to the cardiovascular protection provided by these two drug classes [4, 19]