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Obesity, hyperglycemia, and dyslipidemia are established risk factors for OP, and persons who are obese and diabetic frequently present with concomitant OP (136)

Taken together these data suggest that PLC may have an impact on bladder cancer development, although these experimental results need to be explained by investigation of the molecular mechanisms of PLC signaling

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As such, discontinuing therapy solely based on normalized HbA1c may deprive patients, especially those with underlying cardiovascular or renal risk, of organ-protective effects that are both substantial and sustained