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Surprisingly though, a second-generation GLP-1RA conjugate composed of vitamin B12 and exendin-4 was reported to reduce the adverse reactions, exhibiting improved tolerance (230)
Here is the typical timeline, broken down by phase
doi: 10.1056/NEJMoa1406656 80 DarsaliaVKleinTNystrmTPatroneC
Any larger drops in the first few weeks are predominantly water, glycogen depletion, and reduced food volume in the digestive tract
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