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Conversely, the chronic exposure to the GLP-1RA Exendin-4 (Ex4) reduced the hypothalamic expression of the kisspetptin-1 (Kiss-1) receptors, with a marked reduction of the preovulatory LH peak and a delayed puberty onset [35]

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The direct downstream targets of mTORC1 are ribosomal S6 kinase (p70S6K) and eukaryotic initiation factor 4Ebinding proteins (4EBP) which regulate protein translation, cell size and cell cycle progression 7,8

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