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Moreover, the magnitude of this effect significantly depended on the dosage: median time to death, or ventilation support, was 570 days for placebo, 1,087 days for 25 mg, and 1,197 days for 50 mg methylcobalamin groups

The mouse study reported no observed adverse effects at its tested dose, but that does not establish human safety at any dose or route

It must be combined with an appropriate drug or solute to produce an approximately isotonic solution before IV administration

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