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Of note, only the first two years of observation time from LEADER were considered in the model selection to align with the durations of the trials included in the SUSTAIN and PIONEER programs

It may be that an asparagine can function similarly in a gating capacity to the aspartate, and that association of this variant to SPCD involves a more complex mechanism beyond substrate transport alone

Current opinion in clinical nutrition and metabolic care , 15 (2), 181187

Nevus spilus can present as a congenital or acquired nevoid disorder with the initial presentation often similar to a caf-au-lait patch and subsequent development of superimposed pigmented nevi