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In patients with mutations in the C9ORF72 gene, the production of harmful dipeptide repeat proteins further disrupts communication between the nucleus and cytoplasm, impairing cell function

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This enhancement was likely attributed to the improved stability and cellular uptake of the nanocomplex

Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via nrf2/are/nf-Kb signal pathway

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These observations suggest that AOD9604 may interact with cartilage metabolism and joint remodeling pathways, making it a candidate tool for investigating chondrocyte activity, matrix turnover, and osteoarthritic progression in preclinical models