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In mammals, LC treatment activated the main marker proteins of mitophagy, such as PINK1, Parkin, BCL2/adenovirus E1B 19 kDa protein interacting protein 3 (BNIP-3) and microtubule-associated protein 1 light chain 3 B-II (LC3B-II) (Reference Sabry, Ahmed and Maksoud73,Reference Choi, Ohn and Jung75) , and decreased hepatic 8-hydroxydeoxyguanosine in rats (Reference Chang, Nishikawa and Nishiguchi79)

(PubMed) Termanini B, Gibril F, Sutliff VE, Yu F, Venzon DJ, Jensen RT

(2) Process for requesting an ECE

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Long-term safety of growth hormone in adults with growth hormone deficiency: overview of 15 809 GH-treated patients