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Cluster-3 consisting of N- linker-2-chloroacetamides was mostly inactive, suggesting that inclusion of additional linker groups between the chloroacetamide moiety and the aromatic centre decreased its electrophilic nature and negatively affected potency

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6.1.2.2 Primary efficacy results Clinical results demonstrated that compared to placebo, once-daily 10 mg or 25 mg brensocatib significantly extended time to first acute exacerbation

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