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For instance, abnormally high matrix stiffness can induce a paracrine lipid metabolic crosstalk between stromal and cancer cells, enabling tumors to circumvent the effects of anti-angiogenic therapies [97]

Some peptides are FDA approved for specific medical uses, but many of the peptides discussed for general inflammation, healing, and brain health remain investigational or are limited to compounding under shifting rules

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Massague J, Sheppard D

These differences reflect variations in receptor expression, lipoprotein lipase activity, and hormonal sensitivity between fat depots