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Some research suggests MOTS-c may influence signaling associated with muscle metabolism

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA- c) is a small peptide comprised of 16 amino acids, which is encoded by DNA not in the nucleus, but inside the mitochondrial genome, specifically inside the gene that encodes the mitochondrial 12S ribosomal RNA

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FDA registration is a legal requirement for supplement manufacturers

This rarity will mean that large sample sizes will be required to detect relative differences and avoid error

These central effects complement peripheral mechanisms and contribute to the overall gastric motility changes observed with GLP-1 RA therapy [16]