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Gluconolactone, an outcome of hepatic glucose metabolism, stands as a precursor for ascorbic acid synthesis

Some medications such as metformin and proton pump inhibitors (omeprazole for example) can interfere with the ability to absorb vitamin B12

Nature communications , 12 (1), 470

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The most frequently observed non-HLA genes associated with T1D are the genes encoding insulin (INS), protein tyrosine phosphatase, non-receptor type 22 (PTPN22), cytotoxic T-lymphocyte-associated protein 4 (CTLA4), interleukin-2 receptor alpha (IL2RA), and interferon-induced with helicase C domain 1 (IFIH1)