A., & Schaer, P
50,56,57 It is indicated by its downregulation after being incorporated into macrophages
Similar content being viewed by others Introduction Aging is characterized by the gradual loss of physiological function over time
Hallmark features of AD pathology include (I) age-dependent neurodegeneration that often manifests as gross neuroanatomical changes 12 - 14 , (II) the accumulation of pathological protein aggregates such as A plaques and neurofibrillary tangles (NFTs) 12 , (III) proliferation of glia (gliosis) and alterations in glial function that disrupt neuroimmune function and the blood brain barrier 12 , 15 , and (IV) an altered cellular landscape featuring multifaceted changes in cell signaling and metabolism, excessive oxidative stress, dysfunctional autophagy, impaired cell transport, and synaptic dysfunction 16 - 19
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