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E1 is a thiamin pyrophosphate (TPP)-dependent -ketoacid dehydrogenase, R -lipoic acid functions as a prosthetic group essential for E2 transacetylase activity, and E3 is a flavin adenine dinucleotide (FAD)-dependent dihydrolipoamide dehydrogenase ( Figure 4 )

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Furthermore, cytokines are small proteins that play an important role in cell signaling and immune function

Nitric oxide also plays a role in iron trafficking because it mimics the consequences of iron starvation and triggers iron uptake by cells

This dual inhibition strategy allows HSV-1 to circumvent major apoptotic pathways while promoting both survival and proliferation within host environments (53)