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First clinical trial to investigate the efficacy and safety of combined SGLT2 inhibitor and GLP-1R agonist therapy in patients with T2DM, suggesting additive or synergistic effects on weight loss
If these cost much less, I dont think there would be a debate about coverage given their clinical effectiveness, he says
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Subsequent clinical success demonstrated that these liabilities could be mitigated through slower absorption kinetics, extended dosing intervals, and careful titration, ultimately allowing the beneficial metabolic effects to dominate the riskbenefit profile (Drucker, 2018
Monitor for potential adverse effects including persistent gastrointestinal symptoms, signs of pancreatitis (severe abdominal pain radiating to the back), gallbladder disease (right upper quadrant pain, especially after meals), or changes in mood
Cognitive techniques from CBT can help to identify and challenge general and diabetes-specific cognitive distortions resulting in maladaptive behavior and are usually complemented with behavioral techniques, including behavioral activation and specific behavioral change strategies related to diabetes and mood [218]
