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The pharmacokinetics of FOXO4-DRI, including its administration routes, are a focal point of ongoing research, especially in terms of optimizing its delivery and minimizing off-target effects

The authors compare multiple senolytic strategies including FOXO4-DRI, dasatinib plus quercetin, navitoclax, and fisetin, evaluating mechanisms of action, selectivity profiles, and safety considerations for each approach

Im the absence of CVOTs for most of the newer molecules is it fair to reach a conclusion about CV effects

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