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Beuckmann CT, Fujimori K, Urade Y, Hayaishi O

BV has been shown to increase the expression and levels of several pro-apoptotic mediators, such as cytochrome C, Bcl-2-associated X protein (Bax), protein 53 (p53), Bcl-2 homologues antagonist/killer (Bak), caspase-3, caspase-9, and numerous death receptors while reducing the anti-apoptotic mediator Bcl-2 [37, 38, 52]

In such cases, medical intervention may be necessary to alleviate symptoms and prevent further issues

doi: 10.1155/2022/4236222 531 ZhaoYYuSZhaoHLiLLiYTuYet al

The short answer is yes, and the combination may provide complementary metabolic benefits when used under clinical guidance