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Molecular pathways documented in preclinical research include: (1) activation of nitric oxide (NO) synthesis via L-arginine/eNOS pathway, (2) transcriptional upregulation of VEGF-A and FGF-2 favouring angiogenesis, (3) modulation of the Egr-1 early transcription factor involved in fibroblast proliferation, (4) interaction with 5-HT2A and dopaminergic receptors in some behavioural models, (5) stabilisation of endothelial function via eNOS modulation and reduction of oxidative stress (8-OH-dG, MDA)

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The effects of intratendinous and retrocalcaneal intrabursal injections of corticosteroid on the biomechanical properties of rabbit Achilles tendons

This observation corroborates our previous finding, that an amino acid change to proline in that region of DIII supported this natural bend and prevented the transition into postfusion conformation and therefore inhibited membrane fusion 16

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(1990), The extent of circling of rats was graded from 0 (no circling) to 4 (always circled) at 3 and 7 days after ICH induction