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In this regard, in the recent years, new approaches including the recruitment of nanotechnology in targeted topical drug delivery have been considered to overcome these drawbacks and cause optimum clinical response (Salvioni et al., 2021) Therefore, different types of nanoparticles including lipid nanoparticles, nanoemulsion/microemulsion, vesicular nanocarriers, polymeric nanoparticles, nanocrystals, and metal nanoparticles have been used as topical drug delivery systems for melasma management

Glutathione exists in two states: Reduced Glutathione (GSH): This is the "active" form, ready to neutralise free radicals

For example, curcumin has been integrated with standard chemotherapy agents, including doxorubicin, cisplatin, and paclitaxel, to enhance cancer treatment efficacy (Tan and Norhaizan, 2019)

Quality Sleep: Studies suggest that oxidative stress increases when you are sleep-deprived, which can rapidly deplete your internal antioxidant levels

Similarly, UV light can provide the energy to break down chemical bonds

Despite the value of experimental animal models, a conclusion on the impact of G6PD deficiency on inflammation deserves some caution