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Gluconeogenesis : The bodys process of making glucose (sugar) from sources other than carbohydrates, like protein or fat, which helps maintain energy levels

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Tirzepatide is composed of 39 amino acids, is amidated at the C-terminal, conjugates a C20 fatty diacid moiety via a spacer connected to Lys 20 , and has a half-life of 116.7 h

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In 2023, Juan P Frias and colleagues, in The Lancet, published the first phase two clinical trial of orforglipron, which investigated the use of a small-molecule oral GLP-1R agonist called orforglipron in type 2 diabetes, which can be taken at any time of the day without restrictions on food and water intake (Frias et al., 2023)