Not approved for human consumption, veterinary use, or clinical application.
These include: Nausea (the most frequently reported adverse effect) Vomiting Diarrhoea Constipation Decreased appetite (which, while contributing to weight loss, can occasionally be excessive) These effects were generally mild to moderate in severity and occurred most frequently during the dose-escalation phase
The latest block includes a swathe of smaller companies such as Strut Health, PharmaZee, Lean Rx, and influencer and TV personality Savannah Chrisley's GoodGirlRx that are operating weight-loss programmes based on providing compounded versions of Novo Nordisk's GLP-1 agonists semaglutide and liraglutide and Lilly's dual GIP/GLP-1 agonist tirzepatide
They were randomized to receive 1 mg, 4, mg, 8 mg, or 12 mg doses of retatrutide or to placebo for 48 weeks
FDA Decision (approx
Long-Term Safety Considerations As a relatively new class of medications, the long-term safety profile of GLP-1 agonists is still under evaluation