oral melanotic macule histology macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Oral melanocytic nevi: a clinicopathologic

doi: 10.1111/jfbc.13140 54 BlazevitsODi TanoMLongoVD

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Negative bias from analog methods used in the analysis of free thyroxine in rat serum containing perfluorooctanesulfonate (PFOS)

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The core feature of cleavable linkers is the presence of chemical structures that respond to specific biological conditions, such as peptide bonds (e.g., Val-Cit sequence) recognized by lysosomal proteases like Cathepsin B, hydrazone bonds sensitive to acidic environments, and disulfide bonds that can be reduced under reductive conditions

Other potential confounding factors, such as differences in SOC, patient selection criteria, and GC use patterns, cannot be ruled out