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Treatment with both 1 and 2 SEMA did not influence HDL levels

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Clinical trials show semaglutide produces 15 to 22 percent weight loss versus 2 to 3 percent for metformin, demonstrating the potency difference between appetite regulation and metabolic adjustment

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Women using oral contraceptives should be advised to consider non-oral or additional barrier contraception for 4 weeks after initiation and following each dose increase