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( Erratum in: N Engl J Med
Ascorbate can be regenerated from its oxidized forms, monodehydroascorbate (MDHA) and dehydroascorbate (DHA), by MDHA and DHA reductases (MDHARs and DHARs), respectively (Smirnoff, 2018) The activity of DHARs is coupled to oxidation of glutathione, which is also required for spontaneous, non-enzymatic reduction of DHA to ascorbate (Figure 1)
The GLP-1 receptor agonist, liraglutide, fails to slow disease progression in SOD1(G93A) and TDP-43(Q331K) transgenic mouse models of ALS
Antonia SJ, Villegas A, Daniel D, Vicente D, Murakami S, Hui R, et al