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The use of stomach acid-resistant capsules further protect stability

But they come with risks, research gaps, and liability concerns

Proton pump inhibitors (PPIs) and H2-receptor antagonists reduce gastric acid production, impairing the release of B12 from dietary proteinsthough intrinsic factor-mediated absorption of synthetic B12 remains largely intact

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Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice