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Upon stimulation by Th17 and Th1 cytokines, keratinocytes activate intracellular signaling pathways particularly NF-B, MAPK, and STAT3 which regulate gene transcription involved in inflammation, proliferation, and cell survival

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doi: 10.2174/1871525716666180724115132 52 GarshickMSTawilMBarrettTJSalud-GniloCMEpplerMLeeAet al

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In 2007--2008, the prevalence of American adults having a BMI greater than 30 was 32.2% among men and 35.5% among women [4]

Consistent with this, exogenous -KG supplementation can enhance Arg1 expression and suppress iNOS expression, and changes in metabolic ratios such as -KG/succinate are closely associated with the activation of M2-related transcriptional programs ( It should be noted that the effects of Gln metabolism on polarization direction are markedly context-dependent