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The inactive structure of GLP-1R presented here aligns nicely with a possible role of the GLP-1R ECD as a negative regulator of GLP-1R, although, in contrast to GCGR, we and others have failed to identify mutations in the ECD/ECL interface that increase basal activity of GLP-1R
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key role of GLP-1R
Astrocytes as key regulators of brain energy metabolism: New therapeutic perspectives
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Causing fat loss while maintaining muscle mass would therefore be an attractive feature of a novel therapeutic (Versanis bimagrumab may be differentiated here)
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