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No studies have directly compared the effects of retatrutide and other GLP-1 medications, but vomiting may have been slightly more common in retatrutide trials than in trials for currently available options

This cycle was repeated four times, ensuring that each rat was exposed to every dose, which allowed for within-subject comparisons

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Key weight loss results at 48 weeks by group: Response rates at 48 weeks (12 mg dose): 100% achieved greater than or equal to 5% weight loss 93% achieved greater than or equal to 10% weight loss 83% achieved greater than or equal to 15% weight loss The cardiometabolic improvements were also significant, with reductions in blood pressure, triglycerides, LDL cholesterol, HbA1c, fasting glucose, and fasting insulin across all dose groups