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The generic must demonstrate that its product is pharmaceutically equivalent (same active ingredient, dosage form, route of administration, and strength) and bioequivalent (no clinically significant difference in rate and extent of absorption) to the RLD

(5.1) Diabetic Ketoacidosis in Patients with Type 1 Diabetes Mellitus and Other Ketoacidosis: Consider ketone monitoring in patients at risk for ketoacidosis, as indicated

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For constipation: Increase fluid intake and dietary fiber gradually Consider over-the-counter osmotic laxatives like polyethylene glycol if recommended by your provider For diarrhea: Focus on hydration with electrolyte-containing fluids Over-the-counter loperamide may be appropriate for short-term use if approved by your provider Dose management strategies: If nausea is severe, discuss with your healthcare provider whether slowing the titration schedule is appropriate

Damaged mitochondria that escape degradation act as persistent inflammatory stimuli, linking mitochondrial instability directly to autoimmune disease mechanisms

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